Spermidine has been shown to delay ageing in humans. It is known as a geroprotector, with most benefits coming via autophagy. Spermidine is shown to:

• Extend lifespan.
• Improve resistance to stress.
• Decrease the occurrence of age-related diseases.
• Prevent the loss of movement.
• Protect the heart.
• Protect the cardiovascular system.
• Protect the immune system.

Spermidine has also been shown to upregulate sirtuin 1, prevent liver damage and cancer, act as an anti-inflammatory and even promote human hair growth. It may also protect telomere length.

Spermidine may slow down human ageing, prevent age-related disorders, increase sirtuin 1, defend against liver damage, have anti-inflammatory effects, and improve cognition, all while warding off diseases of the brain including dementia and Parkinson’s, according to studies.

One of spermidine’s most prominent benefits is its effect on the brain. Spermidine can protect your memory, boost your cognitive abilities and stop neurodegeneration.

Levels of spermidine decrease as we age, and a higher spermidine intake reduces the chance of dying.

Useful links:

• Spermidine delays aging in humans
• Molecular basis of the ‘anti-aging’ effect of spermidine and other natural polyamines
• The Quest to Slow Ageing through Drug Discovery
• Cardioprotection and lifespan extension by the natural polyamine spermidine
• Spermidine Promotes Cardioprotective Autophagy
• Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function
• Induction of autophagy by spermidine promotes longevity
• Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
• The Autophagy Enhancer Spermidine Reverses Arterial Aging
• Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway
• Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma
• Autophagy in malignant transformation and cancer progression
• Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
• Molecular Basis of the ‘Anti-Aging’ Effect of Spermidine and Other Natural Polyamines
• Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions
• A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study
• Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
• Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
• Spermidine protects against α-synuclein neurotoxicity
• Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans
• Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
• The positive effect of spermidine in older adults suffering from dementia
• Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage
• (PDF) Induction of autophagy by spermidine promotes longevity
• Higher spermidine intake is linked to lower mortality: a prospective population-based study