SENESCENT CELLS

Senescence is the loss of a cell’s power of division and growth. Once a cell becomes senescent, it remains active and can release harmful substances that may cause inflammation and damage to nearby healthy cells. This is why they are often called “zombie” cells. Senescent cells accumulate as we age. Senescent cells may play a role in the development of cancer and other diseases.

Removing senescent cells is important for health as we age. Something that removes senescent cells is called a “senolytic”. The most potent senolytic we know of is fisetin.

Useful links:

• Targeting cellular senescence prevents age-related bone loss in mice – PMC
• Senolytics improve physical function and increase lifespan in old age | Nature Medicine
• Fisetin is a senotherapeutic that extends health and lifespan – PMC
• The role of senescent cells in ageing – PMC