S I R T 6 ACTIVATOR®

Sirtuin 6, also called the “longevity sirtuin”. SIRT6 enhances DNA double-strand break repair under oxidative stress. Oxidative stress can damage all components of the cell, including DNA. SIRT6 is the only sirtuin that can bind NAD without first having to bind an acylated substrate. SIRT6 recruits PARP1 to facilitate DNA repair and is also instrumental in energy creation as it increases the efficiency of ATP production. SIRT6 has been shown to be closely related to a number of metabolic pathways and genome maintenance, as well as telomere stability.

SIRT6 is neuroprotective, and patients with Alzheimer’s disease have low levels of SIRT6. Activating SIRT6 may provide broad tumour suppressant and health-promoting benefits.

SIRT6Activator® is a seaweed compound especially tested to confirm SIRT6 activation properties, similar to what is seen in centenarians. Seaweed compounds can also have:

• Anti-oxidant effects.
• Anti-tumour effects.
• Anti-coagulant effects.
• Anti-thrombotic effects.
• Immunoregulatory effects.
• Anti-viral effects.
• Anti-inflammatory effects.
• Recently they were shown to give a better immune response after a vaccine.

SIRT6Activator® is a complex polysaccharide derived from seaweed. Laboratory studies suggest that it can prevent the growth of cancer cells and has antiviral, neuroprotective, and immune-modulating effects.

Sirtuin 6, or SIRT6, is a longevity gene. Increased levels of SIRT6 extend lifespan in mammals. Furthermore, long-lived animal species have more active SIRT6. Remarkably, countries with the highest consumption of seaweed, Japan and South Korea, have the longest life expectancies. These ingredients were shown to have multiple health benefits, consistent with pro-longevity function. They improved the immune response to the flu vaccine in the elderly, reduced inflammation, and improved the survival of cancer patients undergoing chemotherapy. There are many varieties of seaweed available on the market, and the end product they produce differs in their chemical formulas. Importantly, SIRT6Activator® has been verified to activate SIRT6.

Boosting NAD levels is another strategy to increase the activity of Sirtuins. However, of all sirtuins, Sirtuin 6 is the least sensitive to NAD concentration. Therefore, to activate Sirtuin 6, it is important to use supplements that activate this enzyme directly.

Useful links:

• Neuroprotective functions for the histone deacetylase SIRT6 – PMC
• Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6: Cell
• Targeting the epigenome in in-stent restenosis: from mechanisms to therapy
• SIRT6 recruits SNF2H to sites of DNA breaks, preventing genomic instability through chromatin remodeling – PMC
• Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging
• SIRT6, a protein with many faces
• Article SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis
• SIRT6 promotes DNA repair under stress by activating PARP1 – PMC
• THE HISTONE DEACETYLASE SIRT6 IS A NOVEL TUMOR SUPPRESSOR THAT CONTROLS CANCER METABOLISM – PMC
• SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
• SIRT6: a promising target for cancer prevention and therapy
• SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells – PMC
• Therapeutic Effects of Fucoidan: A Review on Recent Studies – PMC
• Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination
• Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair – PMC
• Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination
• The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
• Nutrition and metabolism Protocol
• The potential of brown-algae polysaccharides for the development of anticancer agents: An update on anticancer effects reported for fucoidan and laminaran
• Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study
• SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair – PMC
• The central role of DNA damage in the ageing process
• DNA Damage: Health and Longevity – PMC
• Genomics of human longevity – PMC
• SIRT6 protects against pathological damage caused by diet-induced obesity