CA-AKG

Alpha Ketoglutarate is a molecule found naturally in the human body. As we age, its levels decrease. It is vital in the KREBS cycle (energy) and it aids the mitochondria (power packs of the cell). It has shown promise in inhibiting MTOR, activating AMPK, protecting stem cells, protecting healthy bones and even helping with collagen production.

Calcium Alpha Ketoglutarate has been shown to reduce age-related inflammation, maintain DNA structure, detoxify the body, boost glutathione levels, reverse greys and most impressively, extend healthspan by 41%.

Ca-AKG has also been shown to:

• Help with weight loss.
• Extend your healthy lifespan.
• Convert white fat into brown fat.
• Reduce the inflammation from senescent cells.
• Strengthen bones.
• Change the colour of hair/fur
  

  Useful links:

  • Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
  • α-ketoglutarate for myocardial protection in heart surgery – The Lancet
  • Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
  • Alpha-Ketoglutarate: Physiological Functions and Applications
  • The Metabolic Intermediate Alpha-Ketoglutarate Suppresses the TGFβ-driven Profibrotic Responses of Dermal Fibroblasts – ACR Meeting Abstracts
  • Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice
  • Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
  • Dietary alpha-ketoglutarate partially prevents age-related decline in locomotor activity and cold tolerance in Drosophila melanogaster
  • Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK – PMC
  • Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice
  • Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: Cell Metabolism
  • Glutamine and α‐ketoglutarate as glutamate sources for glutathione synthesis in human erythrocytes – Whillier – 2011 – The FEBS Journal – Wiley Online Library
  • Utilization of Alpha-Ketoglutarate by Red Blood Cells for Glutathione Synthesis | Nature